Systemic treatment of human trichomoniasis with a derivative of nitro-imidazole, 8823 RP.

The local treatment of trichomonal vaginitis usually results in cure, but there are the following exceptions: (1) Some cases are resistant to treatment from the start. (2) Local treatment of the vagina can have no effect upon infection of the urethra, from which the vagina is re-infected. (3) In trichomonal urethritis in the male, local methods of treatment up to now have been of little effect, and the logical treatment is systemic. (4) Very occasionally the Trichomonas spreads from its ordinary sites of infection and cannot then be affected by the methods of local treatment currently used.